Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/9141
Title: Hybrid Drug Delivery System- a novel approach
Researcher: Mohamed Saifulla P
Guide(s): Pramod Kumar T M
Keywords: Pharmaceutical Sciences
Pharmacy
Hybrid Drug Delivery System
Candidiasis
Cancer
IPEC
Upload Date: 24-May-2013
University: JSS University
Completed Date: 2012
Abstract: The present study is on the development of Hybrid drug delivery systems for candidiasis and cancer therapy. A hybrid drug delivery system is an unique dosage form, wherein the same mucoadhesive tablets can be delivered through multiple routes, either through oral/vaginal route for candidiasis and oral/vaginal/rectal route for cancer therapy. The effectiveness of the specialized drug delivery systems has been enhanced with the use of different combination of polymers in the form of interpolyelectrolyte complex (IPEC). Miconazole nitrate (MN) tablets were formulated for oral/ vaginal candidiasis using chitosan, carbopol 71G, carboxymethyl tamarind, IPEC. Chitosan, polycarbophil, sodium alginate, IPEC alone and in combination of different concentration ratios has been used in the formulation of 5-fluorouracil (5-FU) tablets for oral/cervical/colorectal cancer. IPEC were characterized by FT-IR, DSC and XRD studies. The tablets were fabricated by direct compression method using 8 mm flat-faced punches in KBr press and were evaluated for pre and post compression properties. Formulations containing IPECs showed pH independent controlled MN/5-FU release in buccal, vaginal pH/ buccal, vaginal and rectal pH respectively. In vitro mucoadhesion studies of IPECs formulations exhibited minimal mucoadhesive strength; moreover addition of other polymers to IPECs enhanced mucoadhesive strength. In vivo X-ray studies showed formulations were intact and adhered to the mucous membrane for over 8 h. Results of the stability studies showed that there were no significant changes in tablet properties. In conclusion, such type of hybrid drug delivery systems may be designed for those drugs which are intended to deliver through oral/vaginal/ rectal route.
Pagination: xi, 290p.
URI: http://hdl.handle.net/10603/9141
Appears in Departments:College of Pharmacy

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01_title.pdfAttached File375.65 kBAdobe PDFView/Open
02_certificates.pdf333.58 kBAdobe PDFView/Open
03_acknowledgment.pdf14.72 kBAdobe PDFView/Open
04_abstract.pdf7.2 kBAdobe PDFView/Open
05_contents.pdf117.7 kBAdobe PDFView/Open
06_list of tables figures & abbreviations.pdf142.63 kBAdobe PDFView/Open
07_chapter 1.pdf183.44 kBAdobe PDFView/Open
08_chpater 2.pdf87.97 kBAdobe PDFView/Open
09_chapter 3.pdf119.5 kBAdobe PDFView/Open
10_chapter 4.pdf718.5 kBAdobe PDFView/Open
11_chapter 5.pdf531.42 kBAdobe PDFView/Open
12_chapter 6.1.pdf1 MBAdobe PDFView/Open
13_chapter 6.2.pdf873.76 kBAdobe PDFView/Open
14_chapter 6.3.pdf1.02 MBAdobe PDFView/Open
15_chapter 6.4.pdf1.07 MBAdobe PDFView/Open
16_summary and conclusion.pdf191.69 kBAdobe PDFView/Open
17_reference.pdf342.94 kBAdobe PDFView/Open
18_annuxures.pdf318.06 kBAdobe PDFView/Open
19_publication 1.pdf325.12 kBAdobe PDFView/Open
20_publication 2.pdf579.91 kBAdobe PDFView/Open


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