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Title: Synthesis Modification and Biological Studies of Pyridazine Analogues
Researcher: Javed, Athar
Guide(s): Sapra,Sameer
Keywords: Clinical Pre Clinical and Health,Pharmacology and Toxicology,Pharmacology and Pharmacy
University: Shoolini University of Biotechnology and Management Sciences
Completed Date: 2018
Abstract: newline x newlineABSTRACT newlineSince pyridazine analogues are not traditionally found in nature, so pyridazine analogues are studied off late. Recently, much attention has been focussed on pyridazine analogues for their broad spectrum biological activities. The present investigation about synthesis, characterization and biological studies of some new pyridazine analogues were carried out to obtain potent and pharmacologically active substances. Medicinal Chemistry establishes a relationship between chemical structure and biological activity. So keeping in view, the biological and pharmacological importance of the pyridazine analogues and other moieties, it is our endeavour, to attach pyridazine ring with various anilines by appropriate synthetic route. From the results of physicochemical and spectral data, it can be concluded that the synthetic work yielded the desired intermediates and final products. newlineDocking studies to estimate the anti-inflammatory activity of all the compounds was performed by using Albumin denaturation assay was performed for the compounds having good docking score. Pyridazine analogs having good albumin denaturation activity were subjected to in-vivo anti-inflammatory activity using carrageenan induced paw edema method and compounds with electron withdrawing groups were found to be most potent compounds. newlineIn order to assess the broad spectrum anti-microbial nature of all the synthesized compounds, the antimicrobial activity was performed against five bacterial stains and two fungal stains. A compound containing hydroxyl groups and carboxyl groups was found to be most active. newlineFrom the results of the anti-inflammatory and antimicrobial activity, it is concluded that pyridazinephenylamine ring was confirmed to be an appropriate scaffold to support the anti-inflammatory and antimicrobial activity, and its modification at the phenyl ring led to the identification of additional active compounds. The results of the present study strongly support the newly synthesized compounds poss
Pagination: 98
Appears in Departments:Faculty Of Pharmacy

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01 front page.pdfAttached File20.39 kBAdobe PDFView/Open
02 certificate.pdf249.19 kBAdobe PDFView/Open
03 contents.pdf8.28 kBAdobe PDFView/Open
04 acknowledgement.pdf95.58 kBAdobe PDFView/Open
05 abbreviations and symbols.pdf92.34 kBAdobe PDFView/Open
06 list of tables.pdf84.64 kBAdobe PDFView/Open
07 list of figures.pdf107.1 kBAdobe PDFView/Open
08 abstract.pdf82.68 kBAdobe PDFView/Open
09 introduction.pdf475.16 kBAdobe PDFView/Open
10 review of lliterature.pdf131.46 kBAdobe PDFView/Open
11 materials and methods.pdf334.52 kBAdobe PDFView/Open
12 results and discussion.pdf1.13 MBAdobe PDFView/Open
13 summary and conclusion.pdf90.59 kBAdobe PDFView/Open
14 future and recommendation.pdf174.89 kBAdobe PDFView/Open
15 references.pdf456.78 kBAdobe PDFView/Open
16 iaec certificate.pdf168.28 kBAdobe PDFView/Open

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