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Title: Forced Degradation Study Of Selective H1Antihistaminic Drugs In Bulk And Formulation
Researcher: Shital Sukhabhai Patel
Guide(s): T Yunus Pasha
Keywords: H1-Antihistaminic drugs,Bilastine, Azelastine, Ebastine, HPLC, degradation kinetics, degradation products, HPLC, LC-MS/MS
Physical Sciences,Chemistry,Chemistry Analytical
University: Gujarat Technological University
Completed Date: 07/08/2019
Abstract: quotThe research study demonstrates development and validation of stability indicating HPLC methods for H1-Antihistaminic Drugs (Bilastine, Ebastine and Azelastine), degradation kinetic study; and identification of degradation products of selected drugs by LC-MS/MS study. Moreover, Literature review revealed that reported analytical methods are not adequate to monitor degradation kinetics and to demonstrate the degradation pattern of the drugs in various stress conditions. To estimate selected drugs stability indicating HPLC methods were developed and validated as per ICH guideline. Then they were extended to study degradation kinetics of drugs with different temperatures. newlineFurther degradation products were identified by LC-MS/MS data. The developed HPLC methods are accurate, precise, simple, sensitive and stability indicating and are suitable for routine analysis of drugs in their formulations. Order of degradation reaction was found. LC-MS/MS data confirms that in presence of hydrochloric acid, Bilastine reacts with methanol and produced methyl ester of Bilastine and on reaction with hydrogen peroxide Bilastine produces N-oxide of bilastine. LC-MS/MS study reveals that hydrochloric acid does the hydrolysis at ether linkage of Ebastine and Ebastine reacts with oxidizing agent, hydrogen peroxide and produces N-oxide of Ebastine. newlineThis PhD thesis would be useful for providing HPLC methods for routine analysis of selected drugs and they can be extended for bio-analysis of drugs.quot newline newline
Pagination: initial pages-xxivall pages end with page no.-149
Appears in Departments:Pharmacy

Files in This Item:
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10_introduction.pdfAttached File366.97 kBAdobe PDFView/Open
11_literature review.pdf190.96 kBAdobe PDFView/Open
12_aim,objective and rationale.pdf146.92 kBAdobe PDFView/Open
13_chapter 4.pdf338.89 kBAdobe PDFView/Open
14_chapter 5.pdf241.34 kBAdobe PDFView/Open
15_chapter 6.pdf437.65 kBAdobe PDFView/Open
16_chapter 7.pdf309.4 kBAdobe PDFView/Open
17_chapter 7.pdf226.99 kBAdobe PDFView/Open
18_chapter 9.pdf401.61 kBAdobe PDFView/Open
19_chapter 10.pdf354.01 kBAdobe PDFView/Open
1_declaration.pdf55.53 kBAdobe PDFView/Open
1_title page.pdf56.96 kBAdobe PDFView/Open
20_chapter 11.pdf93.7 kBAdobe PDFView/Open
3_certificate.pdf51.48 kBAdobe PDFView/Open
4_abstract.pdf55.01 kBAdobe PDFView/Open
5_acknoledgement.pdf66.1 kBAdobe PDFView/Open
6_table of contents.pdf66.82 kBAdobe PDFView/Open
7_abbreviation.pdf62.66 kBAdobe PDFView/Open
8_list of figures.pdf70.19 kBAdobe PDFView/Open
9_list of tables.pdf65.98 kBAdobe PDFView/Open

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