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dc.description.abstractIn this research work, we had tried to synthesize some new heterocyclic compounds. 1-(2 -n-butylbenzofuran-3 -yl) ethanone was condensed with aromatic aldehydes in the presence of aqueous sodium hydroxide to obtain chalcones.The chalconeswere condensed with hydrazine hydrate, hydrazine in glacial acetic acid and phenyl hydrazine to produce pyrazolines derivatives. The chalconeswere reacted with hydroxy amine to obtain isoxazoles. The chalconeswere condensed with urea, thiourea, guanidine hydrochloride to yields pyrimidines derivatives. The chalcones were condensed with malononitrile and pyridine to obtain cyanopyridines derivatives. The cyanopyrans derivatives were obtained by the reaction of chalcones and malononitrile, ammonium acetate, sodium methoxide. Quinoxlines, barbitones and thiosemicarboximide derivatives were obtained by the condensation of chalconeswith orthophylenediamine, barbutric acid, thiosemicarbazide. The mannich bases were synthesized by the condensation of substituted piperazinecompounds with cyclohexanone and aromatic aldehydes in the presence of hydrochloric acid. The synthesized compounds were assigned with 1HNMR, IR, Mass spectroscopy, TLC and elemental analysis. All the synthesized compounds were tested for their antimicrobial activity by cup-plate method against the Gram +ve , Gram ve Bacteria and fungi. The antimicrobial activity was compared with known standard drugs viz. ampicillin, chloramphenicol, norfloxacin and fluconazole.
dc.format.extentIX, 341
dc.relationNo of Reference 343
dc.titleSynthesis Spectral Studies and Antimicrobial Activities Of Some New Heterocyclic Compounds
dc.creator.researcherRoshan, Rakesh
dc.subject.keywordAntimicrobial activities
dc.subject.keywordMannich base
dc.subject.keywordNuclear Magnetic Resonance
dc.subject.keywordPhysical Sciences,Geosciences,Geochemistry and Geophysics
dc.subject.keywordThin Layer Chromatography
dc.description.noteReference p. 1-23
dc.contributor.guideMatariya, Sandip
dc.publisher.universityRK University
dc.publisher.institutionFaculty of Science
dc.format.dimensions30 cm
Appears in Departments:Faculty of Science - Applied Mathematics

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