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Title: Synthesis Spectral Studies and Antimicrobial Activities Of Some New Heterocyclic Compounds
Researcher: Roshan, Rakesh
Guide(s): Matariya, Sandip
Keywords: Antimicrobial activities
Mannich base
Nuclear Magnetic Resonance
Physical Sciences,Geosciences,Geochemistry and Geophysics
Thin Layer Chromatography
University: RK University
Completed Date: 2018
Abstract: In this research work, we had tried to synthesize some new heterocyclic compounds. 1-(2 -n-butylbenzofuran-3 -yl) ethanone was condensed with aromatic aldehydes in the presence of aqueous sodium hydroxide to obtain chalcones.The chalconeswere condensed with hydrazine hydrate, hydrazine in glacial acetic acid and phenyl hydrazine to produce pyrazolines derivatives. The chalconeswere reacted with hydroxy amine to obtain isoxazoles. The chalconeswere condensed with urea, thiourea, guanidine hydrochloride to yields pyrimidines derivatives. The chalcones were condensed with malononitrile and pyridine to obtain cyanopyridines derivatives. The cyanopyrans derivatives were obtained by the reaction of chalcones and malononitrile, ammonium acetate, sodium methoxide. Quinoxlines, barbitones and thiosemicarboximide derivatives were obtained by the condensation of chalconeswith orthophylenediamine, barbutric acid, thiosemicarbazide. The mannich bases were synthesized by the condensation of substituted piperazinecompounds with cyclohexanone and aromatic aldehydes in the presence of hydrochloric acid. The synthesized compounds were assigned with 1HNMR, IR, Mass spectroscopy, TLC and elemental analysis. All the synthesized compounds were tested for their antimicrobial activity by cup-plate method against the Gram +ve , Gram ve Bacteria and fungi. The antimicrobial activity was compared with known standard drugs viz. ampicillin, chloramphenicol, norfloxacin and fluconazole.
Pagination: IX, 341
Appears in Departments:Faculty of Science - Applied Mathematics

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acknowledgement.pdf129.72 kBAdobe PDFView/Open
appendices.pdf184.64 kBAdobe PDFView/Open
certificate.pdf112.14 kBAdobe PDFView/Open
chapter-1.pdf1.8 MBAdobe PDFView/Open
chapter-2.pdf1.18 MBAdobe PDFView/Open
chapter-3.pdf4.15 MBAdobe PDFView/Open
chapter-4.pdf403.58 kBAdobe PDFView/Open
cover page.pdf99.59 kBAdobe PDFView/Open
declaration.pdf110.76 kBAdobe PDFView/Open
graphical abstract.pdf134.24 kBAdobe PDFView/Open
list of abbreviations.pdf100.01 kBAdobe PDFView/Open
list of figures.pdf135.8 kBAdobe PDFView/Open
list of publications.pdf128.53 kBAdobe PDFView/Open
list of tables.pdf139.13 kBAdobe PDFView/Open
refernces.pdf317.4 kBAdobe PDFView/Open
table of contents.pdf156.02 kBAdobe PDFView/Open

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