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Title: Studies on nootropic effects of various extracts of Gemlina arborea and Cayratia trifolia
Researcher: Madiay Darshan Natvarlal
Guide(s): Sunil B Bothara
Keywords: Clinical Pre Clinical and Health,Pharmacology and Toxicology,Pharmacology and Pharmacy
University: Gujarat Technological University
Completed Date: 26th April 2019
Abstract: quotNeurodegenerative disorders, especially Alzheimer s disease (AD) is a serious global health problem. Current scenario of pharmacological treatment of dementia or AD is not satisfactory, as there is no cure for AD with existing medication. newlineThe extensive literary survey was conducted and the plants Gmelina arborea and Cayratia trifolia were selected for the investigations. newlineThe in vivo models used for the study of nootropic activity of extract of Gmelina arborea and Cayratia trifolia were step down passive avoidance, conditioned avoidance response, sodium nitrite induced amnesia and elevated plus maze, while in vitro models includes antioxidant activity by DPPH, NO, estimation of brain reduced glutathione (GSH), estimation of acetyl cholinesterase enzyme activity in mice brain, estimation of brain total protein and estimation of catalase activity. newlineInvestigation marvelously demonstrates the cognitive enhancing and/or anti-amnesic property of the plant preparations in the presence and/or the absence of amnestic agent suggests the nootropic activity of plant preparation of Gmelina arborea and Cayratia trifolia comparable to piracetam. newlinequot newline newline
Appears in Departments:Pharmacy

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02_certificates.pdf146.57 kBAdobe PDFView/Open
03_abstract.pdf85.91 kBAdobe PDFView/Open
04_declaration.pdf71.74 kBAdobe PDFView/Open
05_acknowledgement.pdf53.54 kBAdobe PDFView/Open
06_contents.pdf67.05 kBAdobe PDFView/Open
07_list_of_tables.pdf70.99 kBAdobe PDFView/Open
08_list_of_figures.pdf79.12 kBAdobe PDFView/Open
09_abbreviations.pdf64.76 kBAdobe PDFView/Open
10_chapter1.pdf149.78 kBAdobe PDFView/Open
11_chapter2.pdf1.98 MBAdobe PDFView/Open
12_chapter3.pdf220.55 kBAdobe PDFView/Open
13_chapter4.pdf284.07 kBAdobe PDFView/Open
14_chapter5.pdf158.49 kBAdobe PDFView/Open
15_conclusion.pdf86.14 kBAdobe PDFView/Open
16_bibliography.pdf334.78 kBAdobe PDFView/Open

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