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Title: In vitro and in vivo evaluation studies for some antifungal agents as microspheres
Researcher: Virmani T.
Guide(s): Gupta J.
Keywords: Clinical Pre Clinical and Health,Pharmacology and Toxicology,Pharmacology and Pharmacy
University: MVN University,Palwal
Completed Date: 2018
Abstract: newlineThe prevention and treatment of invasive fungal infections has been a major challenge over the last two decades. Sustained release microspheres of ketoconazole drug were prepared by using one of the best method of preparation of microspheres i.e solvent evaporation method, using cellulose derivative such as ethyl cellulose ( as film forming polymer) and methyl cellulose ( provides shape and integrity to the microspheres) as release rate controlling polymers. The absorption of antifungal drug ketoconazole is enhanced by gastric acidity of the stomach, because drug shows maximum solubility at acidic pH and hence it was an idea to prepare sustained release product which can be given by oral route and may overcome the side effects related with conventional dosage forms. 4 to 6 hrs of half life and molecular weight of 400 to 600 Dalton will be the ideal candidate for the preparation of controlled drug delivery system. 2 X 2 factorial design was selected for optimization of the amount of polymers to be used. The surface images of the sustained release microspheres were characterized by scanning electron microscopy. The prepared microspheres were characterized by their micromeritics properties such as particle shape and size, interquartile coefficient of skewness and kurtosis. Dissolution data obtained from in vitro release studies fitted Higuchi and Peppas model with a diffusion coefficient of 0.72 value, recommend the drug release mechanism as non fickian diffusion. The release profile of KTZ could be represented by Jander s equation, exhibiting pH- dependency and therefore the release of KTZ was governed by the diffusion within the microspheres and the solubility. Microspheres prepared by solvent evaporation method using antifungal agent i.e Ketoconazole exhibit controlled release behavior, which was based on pH as diffusion controlled release behavior without matrix erosion. Comparative % drug release of various variables shows significant effects as compared to drug loaded microspheres.
Appears in Departments:Pharmaceutical Science

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02_certificate.pdf383.23 kBAdobe PDFView/Open
03_abstract.pdf11.71 kBAdobe PDFView/Open
04_acknowledgement.pdf10.64 kBAdobe PDFView/Open
05_table of contents.pdf18.1 kBAdobe PDFView/Open
06_list of tables.pdf96.42 kBAdobe PDFView/Open
07_list of figures.pdf451.91 kBAdobe PDFView/Open
08_chapter-1.pdf620.75 kBAdobe PDFView/Open
09_chapter-2.pdf301.67 kBAdobe PDFView/Open
10_chapter-3.pdf818.68 kBAdobe PDFView/Open
11_chapter-4.pdf340.48 kBAdobe PDFView/Open
12_chapter-5.pdf499.72 kBAdobe PDFView/Open
13_chapter-6.pdf718.98 kBAdobe PDFView/Open
14_chapter-7.pdf525.94 kBAdobe PDFView/Open
15_chapter-8.pdf149.64 kBAdobe PDFView/Open
16_references.pdf455.55 kBAdobe PDFView/Open
17_list of publication.pdf149.45 kBAdobe PDFView/Open

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