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Title: Development of Nanotextiles for Vascular Graft Applications
Researcher: John Joseph
Guide(s): Deepthy Menon , Sahadev Shankarappa
Keywords: Clinical Pre Clinical and Health
Clinical Medicine,Medicine Research and Experimental
Fabrication technique; Nanofibers
University: Amrita Vishwa Vidyapeetham (University)
Completed Date: June 2018
Abstract: This study investigated the unique properties, fabrication technique and vascular graft applications of woven nanotextiles made from low strength nanoyarns, which are bundles of thousands of nanofibers. These nanoyarns were fabricated by a novel process wherein the electrospun fibers were captured and twisted by a rotating collector with unique design that provided a pressuredriven, localized cotton-wool structure in free space referred to as substrate-less electrospinning . The diameter of the nanoyarns (typically between 100-300 and#956;m) were tuned by changing the process parameters, which were well investigated in this study. In order to convert these nanoyarns to tubular nanotextiles by textile technology, the mechanical strength of the nanoyarns had to be further improved. This was achieved by a post processing technique (heat-stretching) which improved its crystallinity, resulting in higher tensile strength. However, the strength of nanoyarns were not strong enough for them to be processed into tubes via conventional textile machines. Hence, an innovative robotic system was developed to meticulously interweave nanoyarns in longitudinal and transverse directions, resulting in a flexible, but strong woven product. This is the only technique for producing seamless nanotextiles in tubular form from nanofibers. The porosity and mechanical properties of nanotextiles could be substantially tuned by altering the number of nanoyarns per unit area. Investigations into the physical and biological properties of the woven nanotextile revealed remarkable and fundamental differences from its non-woven nanofibrous form and conventional textiles. This enhancement in the material property was attributed to the multitude of hierarchically arranged nanofibers in the woven nanotextiles. This patterned woven nanotextile architecture lead to a superhydrophillic behavior in an otherwise hydrophobic material, which in turn contributed to enhanced protein adsorption and consequent cell attachment and spreading. Short term in vivo testin
Appears in Departments:Amrita Centre for Nanosciences and Molecular Medicine

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01_title.pdfAttached File268.18 kBAdobe PDFView/Open
02_certificate.pdf542.85 kBAdobe PDFView/Open
03_declaration.pdf106.51 kBAdobe PDFView/Open
04_contents.pdf121.97 kBAdobe PDFView/Open
05_acknowledgement.pdf117.01 kBAdobe PDFView/Open
06_abstract.pdf113.9 kBAdobe PDFView/Open
07_abbreviations.pdf88.53 kBAdobe PDFView/Open
08_list of figures.pdf129.76 kBAdobe PDFView/Open
10_chapter 1.pdf3.63 MBAdobe PDFView/Open
11_chapter 2.pdf663.62 kBAdobe PDFView/Open
12_chapter 3.pdf44.24 MBAdobe PDFView/Open
13_chapter 4.pdf135.19 kBAdobe PDFView/Open
14_references.pdf168.73 kBAdobe PDFView/Open
15_publications.pdf104.24 kBAdobe PDFView/Open
9_list of tables.pdf86.37 kBAdobe PDFView/Open

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