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Title: Nanoparticulate Drug Delivery System for Tuberculosis
Researcher: Sujit Kumar Debnath
Guide(s): S Saisivam
Keywords: Engineering and Technology
University: Gujarat Technological University
Completed Date: 29-10-2018
Abstract: The aim of the present investigation is to design and optimize nanoparticles containing anti-tubercular drug in the form of dry powder inhaler that can reach to lungs through pulmonary route and give sustained effect for the period of 24 hr in the lungs. Lungs are mainly affected by the M. Tuberculosis, whereas drug reaches to lungs is very less from oral conventional dosage form. Due to low biological half life, Ethionamide/ Prothionamide excrete rapidly; that necessitated repeated administration with higher dose. Nanoparticles of these drugs can sustain the release and can be targeted the same in the form of dry powder inhaler to lungs. In the present investigation, an attempt was made to design and formulate nanoparticles of Prothionamide/ Ethionamide. These prepared nanoparticles further modified into dry powder inhaler to make suitable for pulmonary administration. By selecting pulmonary route, drug targeting to lungs was achieved and also overcome the problems associated with oral administered drugs. By the use of biodegradable polymer release of Prothionamide and Ethionamide were controlled over the period of 24 hr in lungs. These formulations reduce the dose and dosing frequency and are convenient to administer to pulmonary route. These DPI formulations are cost effective and patient compliance as it is noninvasive delivery. Formulation techniques adopted here are feasible for industrial scale. newline newline
Pagination: 235 pages
Appears in Departments:Pharmacy

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01_title.pdfAttached File56.14 kBAdobe PDFView/Open
02_declaration.pdf13.42 kBAdobe PDFView/Open
03_certificate.pdf304.08 kBAdobe PDFView/Open
04_abstract.pdf25.05 kBAdobe PDFView/Open
05_acknowledgement.pdf29.23 kBAdobe PDFView/Open
06_contents.pdf81.07 kBAdobe PDFView/Open
07_abbreviations.pdf50.54 kBAdobe PDFView/Open
08_list_of_symbols.pdf29.45 kBAdobe PDFView/Open
09_list_of_figure.pdf37.65 kBAdobe PDFView/Open
10_list_of_tables.pdf36.27 kBAdobe PDFView/Open
11_list_of_appendices.pdf8.78 kBAdobe PDFView/Open
12_chapter1.pdf68.47 kBAdobe PDFView/Open
13_chapter2.pdf707 kBAdobe PDFView/Open
14_chapter3.pdf330.06 kBAdobe PDFView/Open
15_chapter4.pdf3.54 MBAdobe PDFView/Open
16_chapter5.pdf77.35 kBAdobe PDFView/Open
17_chapter6.pdf445.63 kBAdobe PDFView/Open
18_chapter7.pdf41.98 kBAdobe PDFView/Open
19_reference.pdf117.89 kBAdobe PDFView/Open
20_bibliography.pdf93.91 kBAdobe PDFView/Open
21_appendix.pdf540.74 kBAdobe PDFView/Open
22_list_of_publications.pdf26.08 kBAdobe PDFView/Open

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