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Title: Brain implantable nano fibrous wafer for prolonged drug delivery against recurrent glioma
Researcher: Ranjith R
Guide(s): Manzoor Koyakutty
Keywords: Glioblastoma Multiforme (GBM); Nano-fibrous polymer implant; Brain implan; Nanoscience;
Physical Sciences
University: Amrita Vishwa Vidyapeetham (University)
Completed Date: 06/2016
Abstract: Delivery of therapeutic agents at clinically relevant doses is very critical in achieving desired treatment response in chemotherapy. Drug delivery to central nervous system tumors, like glioblastoma multiforme (GBM) faces serious challenges due to existence of blood brain barrier, short drug half-life, fast clearance, high plasma protein binding and non-specific biodistribution. Administration of high doses of drugs to overcome these limitations ultimately leads to dose limiting toxicities. This necessitates alternative strategies to attain required dose of drug locally at the tumor site. Local drug delivery methods can overcome most of the above challenges. For the past two decades, there is one only local drug delivery system (Gliadel ) approved by FDA for treating glioblastoma. Gliadel delivers a chemotherapeutic agent, carmustine, in the tumor resected cavity for nearly 6-7 days. Although Gliadel improves patient survival by 2-3 months, recurrence of tumor from 1-2 cm region of resected margin was reported. This is attributed to: i) the inability of implant to release drug for more than 7-14 days, ii) short-half life and fast clearance of carmustine resulting in poor drug-retention and iii) low tissue penetration of the drug. A number of studies have reported the use of alternative implant systems for the localized delivery of various anti-cancer drugs. However, sustained in vivo release for up to a month or more remains to be an unmet challenge. This study investigated the possibility of developing low-cost, bulk-eroding, biodegradable polymer implants for the sustained release of anti-glioma drugs in the brain for at least one month. Although it is difficult to achieve constant and sustained release using bulk eroding polymers, we have optimized an innovative method to overcome this challenge.
Pagination: XXIV, 166
Appears in Departments:Amrita Centre for Nanosciences and Molecular Medicine

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01_title.pdfAttached File26.69 kBAdobe PDFView/Open
02_declaration.pdf72.52 kBAdobe PDFView/Open
03_certificate.pdf177.88 kBAdobe PDFView/Open
04_contents.pdf55.84 kBAdobe PDFView/Open
05_acknowledgements.pdf89.81 kBAdobe PDFView/Open
06_abstract.pdf172.21 kBAdobe PDFView/Open
07_abbreviations.pdf215.91 kBAdobe PDFView/Open
08_list of figures.pdf109.43 kBAdobe PDFView/Open
09_list of tables.pdf182.35 kBAdobe PDFView/Open
10_chapter 1.pdf802.89 kBAdobe PDFView/Open
11_chapter 2.pdf2.94 MBAdobe PDFView/Open
12_chapter 3.pdf697.31 kBAdobe PDFView/Open
13_chapter 4.pdf1.12 MBAdobe PDFView/Open
14_chapter 5.pdf168.7 kBAdobe PDFView/Open
15_appendix.pdf199.28 kBAdobe PDFView/Open
16_publications.pdf192.84 kBAdobe PDFView/Open

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