Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/221375
Title: Detection of red cell alloantibody among the blood transfusion recipients
Researcher: Ali Amran Ziad Nasser Nasser
Guide(s): Mehra Manju, Agarwal Pankaj
Keywords: Clinical Pre Clinical and Health, Alloimmunization; Multiple Transfusions; Blood Grouping; Blood Bank
University: Nims University Rajasthan
Completed Date: 2018
Abstract: Alloantibodies formation against red blood cell antigens is the most common complication of transfusion therapy especially in multiple transfusions and women s negative blood group. Most blood transfusions have done based on cross- matching only. Limited data are available on the frequency of immunization case among patients in Jaipur. Aim: To determine the frequency of red cell alloantibodies in multiple blood transfusions, identify of common alloantibody, reduce complications of blood transfusions, improving the safety of blood transfusions and management and treatment of women having alloantibodies. Materials and Methods: A total of 263 samples were collected from blood transfusions recipient s patients in NIMS and SDM Hospital. Lab tests have done by (BioVue cassettes based on Column Agglutination Technology) in Blood Bank - SDM Hospital includes: ABO, Rh grouping, Du antigen testing, Direct and Indirect Coomb s Test (DCTandICT), Antibody screening 3 cell panel (Ortho BioVue AHG Polyspecific Cassettes), antibody identification using 11 cells panel (Ortho Resolve Panel). Results: Out of 263 patients 127 (48.3%) were males and 136 (51.7%) females. The prevalence of alloimmunization was 18.3% and the most alloantibody frequent case combination was Anti-M (18.7%), E (12.5%), D (12.5%), C (10.3%), c (6.2%), e (4.2%), N newline(6.2%), Fya (4.2%), Lea (4.2%), Leb (4.2%), K (2.1%), Jka (2.1%), Jkb (2.1%), P1 newline(2.1%). Some cases were have dual Anti-E+ Fyb (2.1%), Fyb+S (2.1%) and Anti-D+C (2.1%) while one patient was have triple alloantibodies Anti-C+E+K (2.1%). All alloantibodies were IgG class except Anti-M was IgG and IgM. Female and male immunized ratio was (2.1:1). The most common blood group among our patients was O positive which is detected in 16 patients (33.4%). Conclusion: Many factors may have contributed to the high immunized ratio observed in this study includes heterogeneity of the population living in Jaipur, lack of better-matched donors for those patients, didn t use of leukodepleted blood. They have t
Pagination: 1-18, 1-139
URI: http://hdl.handle.net/10603/221375
Appears in Departments:Department of Medical Lab Technology Paramedical Subjects

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01_title.pdfAttached File82.05 kBAdobe PDFView/Open
02_abstract.pdf98.77 kBAdobe PDFView/Open
03_undertaking research scholar.pdf423.39 kBAdobe PDFView/Open
04_certificate supervisor.pdf509.67 kBAdobe PDFView/Open
05_certificate co supervisor.pdf505.87 kBAdobe PDFView/Open
06_acknowledgement.pdf96.88 kBAdobe PDFView/Open
07_dedication.pdf95.15 kBAdobe PDFView/Open
08_contents with page numbers.pdf113.32 kBAdobe PDFView/Open
09_list of tables.pdf94.9 kBAdobe PDFView/Open
10_list of diagrammes & figures.pdf94.59 kBAdobe PDFView/Open
11_abbreviations & acronyms.pdf105.83 kBAdobe PDFView/Open
12_list of annexures & appendices.pdf94.51 kBAdobe PDFView/Open
13_chapter 1.pdf96.27 kBAdobe PDFView/Open
14_chapter 2.pdf302.65 kBAdobe PDFView/Open
15_chapter 3.pdf734.46 kBAdobe PDFView/Open
16_chapter 4.pdf3.26 MBAdobe PDFView/Open
17_chapter 5.pdf108.64 kBAdobe PDFView/Open
18_chapter 6.pdf53.85 kBAdobe PDFView/Open
19_references.pdf131.04 kBAdobe PDFView/Open
20_bibliography.pdf145.39 kBAdobe PDFView/Open
21_case proforma.pdf105.93 kBAdobe PDFView/Open
22_participation information sheet.pdf97.43 kBAdobe PDFView/Open
23_participant informed consent form.pdf94.77 kBAdobe PDFView/Open
24_list of presentations.pdf95.9 kBAdobe PDFView/Open
25_ethical clearance.pdf541.6 kBAdobe PDFView/Open
26_approval letter for workink from blood bank.pdf334.94 kBAdobe PDFView/Open
27_published paper 1.pdf540.65 kBAdobe PDFView/Open
28_published paper 2.pdf365.53 kBAdobe PDFView/Open
29_conference certificate 1.pdf198.98 kBAdobe PDFView/Open
30_conference paper 1.pdf621.66 kBAdobe PDFView/Open
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32_conference paper 2.pdf502.7 kBAdobe PDFView/Open
33_poster certificate.pdf168.17 kBAdobe PDFView/Open
34_poster presentation.pdf274.01 kBAdobe PDFView/Open
35_master chart.pdf94.86 kBAdobe PDFView/Open


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