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Title: Single Nucleotide Polymorphisms of Signal Transduction Genes in Oral Cancer
Researcher: Multani Sunil Shaleen
Guide(s): Saranath Dhananjaya
Keywords: alcohol
Human Papilloma Virus
Nucleotide Polymorphisms
Oral Cancer
University: Narsee Monjee Institute of Management Studies
Completed Date: 07/03/2017
Abstract: Oral cancer is a major health concern in India with an annual incidence of 77,003 contributing 26% of the global oral cancer burden. The well-established risk factors of oral cancer include tobacco, areca nut, alcohol and Human Papilloma Virus HPV 16/18. However, only a small proportion of high-risk individuals develop oral cancer, implying a role of genomic constitution in susceptibility to oral cancer. Hence, investigation of a panel of genomic variants represented as Single Nucleotide Polymorphisms (SNPs) was the focus of the current project. The SNPs and the genes included were - rs2124437 (RASGRP3); rs1335022 (GRIK2); rs4512367 (PREX2); rs4748011 (CCDC3); rs1435218 (LNX1); rs9843143 (TGFBR2); rs6827096 (EDNRA); rs1821777 (IRAK3); rs1911746 (PTPRG); rs290974 (SYK); rs2156921 (BCR) and rs144761391 (GAPDH) in genes associated with biological functions of critical significance in oral cancer. Further, in silico analysis using structure based virtual screening to identify specific small drug-like molecules as lead molecules for inhibition of kinase activity of TGFBR2 containing SNP rs9843143 indicating high-risk of oral cancer was performed. newlineOur study subjects comprised 500 histopathologically confirmed oral cancer cases and 500 healthy Long Term Tobacco Users (LTTUs) with no history of cancer. The oral cancer patients and LTTUs were tobacco habitu├ęs of minimum 10 year duration. Blood sample (5 ml) was collected from patients and controls. Institute ethics approval from Sunandan Divatia School of Science, Prince Aly Khan Hospital and Cancer Patients Aids Association was obtained. Informed consent was given by the participants for voluntary participation. Demographic data including age, gender, tobacco habits, and clinicopathological profile including cancer tumor size, site, nodal infiltration, differentiation and stage of cancer was recorded for all the participants. newline
Appears in Departments:Department of Biological Sciences

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06_list of tables.pdf147.78 kBAdobe PDFView/Open
07_list of figures.pdf258.03 kBAdobe PDFView/Open
08_ abstract.pdf268.49 kBAdobe PDFView/Open
08_chapter 1.pdf745.68 kBAdobe PDFView/Open
09_chapter 2.pdf946.76 kBAdobe PDFView/Open
10_chapter 3.pdf273.06 kBAdobe PDFView/Open
11_chapter 4.pdf912.07 kBAdobe PDFView/Open
12_chapter 5.pdf4.04 MBAdobe PDFView/Open
13_chapter 6.pdf580.2 kBAdobe PDFView/Open
14_chapter 7.pdf266.85 kBAdobe PDFView/Open
15_reference.pdf383.95 kBAdobe PDFView/Open

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