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Title: Development and validation of chromatographic and spectroscopic methods for estimation of some Antihypertensive agents and their combined dosage forms
Researcher: Ms Avani Harshadkumar Sheth
Guide(s): Nehal J Shah
Keywords: Antihypertensive agents, Olmesartan medoxomil, Indapamide, Chlorthalidone, Rosuvastatin calcium, hydrochlorthiazide, Metoprolol succinate, Nebivolol hydrochloride
University: Gujarat Technological University
Completed Date: 23/05/2018
Abstract: quot newlineThere are numbers of newer antihypertensive drugs and their formulations are approved by FDA which is either new molecule or partial modification of existing molecule. These newer drugs and their combinations are not official in any pharmacopeias and are take more time to include in pharmacopeias. Because of continuous and longer use of these drugs individually newer side effects, toxicity, resistances are observed. newline newlineSo present investigation was undertaken with a view to develop and validate new analytical methods (HPLC and UV/HPTLC) for simultaneous estimation of following combinations newline1. Olmesartan medoxomil and Indapamide tablets newline2. Olmesartan medoxomil and Chlorthalidone tablets newline3. Nebivolol Hydrochloride and Chlorthalidone tablets newline4. Rosuvastatin calcium and Hydrochlorthiazide tablets newline5. Metoprolol succinate and Chlorthalidone tablets newline newline Statistical comparison of developed HPLC methods and UV/HPTLC methods is done for proving equivalency of developed methods. newlinequot newline newline
Pagination: 9.2 MB
Appears in Departments:Pharmacy

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cover annexure _0.pdfAttached File20.4 kBAdobe PDFView/Open
cp_title.pdf20.49 kBAdobe PDFView/Open
d_copyright_declaration_certificate _pg 1_2_3.pdf77.88 kBAdobe PDFView/Open
d_orc_non exc_thesis approval_abstract_ack_pg 4_11.pdf145.07 kBAdobe PDFView/Open
e_table of contents pg 12_13.pdf107.71 kBAdobe PDFView/Open
f_abbreviations_annexure pg 14_15.pdf166.08 kBAdobe PDFView/Open
f_list of figures to be edited_pg 16_18.pdf192.12 kBAdobe PDFView/Open
f_list of tables to be edited_pg 18_23.pdf150.07 kBAdobe PDFView/Open
g_chapter 1 introduction.pdf794.92 kBAdobe PDFView/Open
h_chapter 2 review of literature.pdf569.84 kBAdobe PDFView/Open
i_ chapter 3 aim of work.pdf100.45 kBAdobe PDFView/Open
j chapter 4 chemicals and instruments of research work.pdf173.71 kBAdobe PDFView/Open
k_chapter 5 olmesartan medoxomil and indapamide hplc & uv method.pdf1.32 MBAdobe PDFView/Open
l_chapter 6 olmesartan medoxomil and chlorthalidone hplc & uv method.pdf1.23 MBAdobe PDFView/Open
m_ chapter 7 nebivolol hcl and chlorthalidone hplc & uv method.pdf1.31 MBAdobe PDFView/Open
n_ chapter 8 rosuvastatin calcium and hydrochlorthiazide hplc & uv method.pdf1.48 MBAdobe PDFView/Open
o_ chapter 9 metoprolol succinate and chlorthalidone hplc & hptlc method.pdf1.57 MBAdobe PDFView/Open
p_ chapter 10 statistical comparison of hplc & uv methods.pdf209.66 kBAdobe PDFView/Open
q_ chapter 11 summary and conclusion.pdf167.02 kBAdobe PDFView/Open
r_chapter 12 list of publications.pdf10.74 kBAdobe PDFView/Open
separator.pdf140.09 kBAdobe PDFView/Open

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