Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/206442
Title: Formulation evaluation and development of bioadhesive drug delivery system containing phytopharmaceuticals
Researcher: Ms. Prachiben M. Patel
Guide(s): V.H.Bhaskar
Keywords: Reservoir patch, Matrix Patch, 18 and#946;-glycyrrhetinic acidBoswellic acid, HPMC E50, Piperine, Bioenhancer,Bioadhesive drug delivery system, Antiinflammatory,
University: Gujarat Technological University
Completed Date: 18/11/2017
Abstract: A reservoir type patch of 18 and#946;-glycyrrhetinic acid and matrix type transdermal patch of boswellic acids with piperine as bioenhancer was prepared. Both type of patch were evaluated for physicochemical characteristics, in-vitro, ex-vivo and in-vivo studies. Reservoir F4 patch provided 95.55% in-vitro and 91.58% ex-vivo release of phytopharmaceutical at 10hr. The matrix F10 patch was showed 97.8% in vitro and 93.20% ex vivo release at 10 hr. The anti-inflammatory action of F4 (reservoir) and F10 (matrix) showed 87.36% and 89.77% inhibition of rat paw edema at 10 h. Both type of patch was demonstrated the feasibility for future clinical trials. newline
Pagination: 4.27MB
URI: http://hdl.handle.net/10603/206442
Appears in Departments:Pharmacy

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01_title.pdfAttached File93.59 kBAdobe PDFView/Open
02_copyright.pdf79.21 kBAdobe PDFView/Open
03_declaration and certificate.pdf157.43 kBAdobe PDFView/Open
04_originality report, non exclusive license and thesis approval.pdf164.04 kBAdobe PDFView/Open
05_abstract.pdf125.94 kBAdobe PDFView/Open
06_acknowledgement.pdf125.53 kBAdobe PDFView/Open
07_table of contents.pdf144.79 kBAdobe PDFView/Open
08_list of figures.pdf201.44 kBAdobe PDFView/Open
09_list of tables.pdf191.34 kBAdobe PDFView/Open
10_index.pdf151.93 kBAdobe PDFView/Open
11_chapter 1.pdf833.56 kBAdobe PDFView/Open
12_chapter 2.pdf617.09 kBAdobe PDFView/Open
13_chapter 3pdf.pdf302.61 kBAdobe PDFView/Open
14_chapter 4.pdf758.97 kBAdobe PDFView/Open
15_chapter 5.pdf1.28 MBAdobe PDFView/Open
16_chapter 6.pdf197.38 kBAdobe PDFView/Open
17_chapter 7.pdf209.42 kBAdobe PDFView/Open
18_abbriviations.pdf236.64 kBAdobe PDFView/Open
19_list of publications.pdf1.17 MBAdobe PDFView/Open
files in this item.pdf87.5 kBAdobe PDFView/Open
thesis.pdf.pdf4.38 MBAdobe PDFView/Open


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