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Researcher: Ms.Prachi Pandey
Guide(s): S.S Pancholi
Keywords: Arthritis,novel carrier systems, Transdermal gel
University: Gujarat Technological University
Completed Date: 1-Jul-17
Abstract: quotArthritis is a major cause of disability and morbidity, particularly in older individuals. The symptoms and signs of arthritis and related conditions include pain, stiffness, swelling, muscle weakness, and limitation of movement of the joints. newlineNonsteroidal anti-inflammatory drugs are most widely used and effective drugs for treatment of arthritis. Nonsteroidal anti-inflammatory drugs (NSAIDs) that act by inhibiting cyclooxygenase and the formation of prostaglandins, are known to cause gastrointestinal toxicity, leading to peptic ulcers, cardiotoxicity, renal toxicity and anaphylactic reactions in selected patients. The currently available oral dosage forms of NSAIDs like tablet and capsules etc. are more likely to produce above mentioned adverse effects of these drugs. The intravenous administration of these drugs leads to distribution throughout the whole body and rapid clearance, thus a high and frequent dosing is necessary to achieve an effective concentration of drug at inflamed target sites. Moreover, the activities of drug in many different tissues increase the risk of adverse effects in patients. Transdermal delivery of drugs can be a suitable option and is associated with advantages such as avoidance of hepatic first-pass metabolism and GI adverse effects, improved patient compliance and ease of access, a means to quickly terminate dosing, sustained therapeutic drug levels, possible self administration, non-invasive (no needles or injections needed), avoidance of food related interaction, reduction of doses as compared to oral dosage forms and intravenous therapy. newlineThe trandsermal drug delivery also suffers from some shortcomings such as poor permeability through skin, unpredictable drug release and skin irritation. These shortcomings can be overcome if we develop a drug delivery system in drug carriers which can provide enhanced localization to the target site and sustained drug release. newlineThe objective of the present research work was to develop a drug delivery system for localized action of drugs used in
Pagination: Pages : 238
Appears in Departments:Pharmacy

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02_certificates.pdf.pdf113.11 kBAdobe PDFView/Open
03_abstract.pdf.pdf178.53 kBAdobe PDFView/Open
04_declaration.pdf.pdf55.81 kBAdobe PDFView/Open
05_acknowledgement.pdf.pdf113.43 kBAdobe PDFView/Open
06_contents.pdf.pdf690.51 kBAdobe PDFView/Open
07_list_of_tables.pdf.pdf232.3 kBAdobe PDFView/Open
08_list_of_figures.pdf.pdf346.2 kBAdobe PDFView/Open
09_abbreviation.pdf.pdf60.85 kBAdobe PDFView/Open
10_chapter 1.pdf.pdf1.83 MBAdobe PDFView/Open
11_chapter2.pdf.pdf210.34 kBAdobe PDFView/Open
12_chapter3.pdf.pdf40.48 kBAdobe PDFView/Open
13_chapter4.pdf.pdf1.17 MBAdobe PDFView/Open
14_chapter5.pdf.pdf4.35 MBAdobe PDFView/Open
15_conclusion.pdf.pdf44.92 kBAdobe PDFView/Open
16_references.pdf.pdf83.64 kBAdobe PDFView/Open

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