Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/206427
Title: FORMULATION AND EVALUATION OF ORAL DELIVERY SYSTEMS FOR POORLY ABSORBED DRUGS USED IN OSTEOPOROSIS
Researcher: MILIND MADHAV THOSAR
Guide(s): S S PANCHOLI
Keywords: Oral delivery systems, multiple emulsion, sublingual spray
University: Gujarat Technological University
Completed Date: 01-07-2017
Abstract: Bisphosphonates (BPs) are drugs found useful in physiological regulation of calcification, bone resorption and currently have become drug of choice for the management of osteoporosis. The major drawback of the clinically utilized BPs is their poor oral absorption from the GI tract, typically less than 1% is absorbed which is due to their poor permeability. In addition, the BPs have been associated with undesirable gastrointestinal effects. Risedronate sodium (RIS) is a bisphosphonates popularly indicated for osteoporosis that belongs to BCS Class III and has poor oral bioavailability due to less permeability. The present work attempted to improve poor permeability of RIS through dual approaches, multiple emulsion and sublingual spray formulations which were found promising. In first approach Initially RIS w/o/w multiple emulsion formulations were prepared and evaluated for determining significant causative factors and their effect on formulation properties. Consequently determined causative factors were included in central composite design and total 18 formulations were prepared and evaluated for appearance, pH, globule size, viscosity, % creaming, pourability, drug entrapment efficiency, in vitro drug release, ex-vivo permeation study. Numerically optimized F19 formulation was additionally subjected for zeta potential and stability test. Stability of F19 was improved by including surfactant blend, phase volume ratio and hydrophilic polymer in outer water phase and stabilized F19B was evaluated for in vivo absorption study. The second approach involved formulation of propellant free RIS sublingual spray using face centered central composite design in which independent variables considered were concentration of drug, co-solvent and spreading agent while responses as spray pattern, spray angle and drug permeation and optimized by numerical method to get optimized sublingual spray FO. Total 16 formulations of RIS sublingual spray were prepared. All formulations were evaluated for spray pattern, spray angle, leak
Pagination: CLXXXII, 182 p.
URI: http://hdl.handle.net/10603/206427
Appears in Departments:Pharmacy

Files in This Item:
File Description SizeFormat 
10_chapter4.pdfAttached File2.59 MBAdobe PDFView/Open
11_chapter5.pdf91.9 kBAdobe PDFView/Open
12_references.pdf232.32 kBAdobe PDFView/Open
1_title.pdf79.01 kBAdobe PDFView/Open
2_certificate.pdf138.32 kBAdobe PDFView/Open
3_aknowledgement.pdf86.66 kBAdobe PDFView/Open
4_contents.pdf119.92 kBAdobe PDFView/Open
5_preface.pdf86.7 kBAdobe PDFView/Open
6_list of tables figures .pdf195.12 kBAdobe PDFView/Open
7_chapter1.pdf498.78 kBAdobe PDFView/Open
8_chapter2.pdf301.26 kBAdobe PDFView/Open
9_chapter3.pdf697.86 kBAdobe PDFView/Open


Items in Shodhganga are protected by copyright, with all rights reserved, unless otherwise indicated.