Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/19245
Title: Total Synthesis of naturally occurring lactones and Semiplenamides C and E and Investigation on Novel Diterpenoids of Jatropha Multifida
Researcher: Shashikanth B
Guide(s): Das, Biswanath
Keywords: Jatropha
lactones
Multifida
Semiplenamides
Synthesis
Upload Date: 12-Jun-2014
University: Jawaharlal Nehru Technological University, Hyderabad
Completed Date: 2013
Abstract: The present study is focussed on the stereoselective total synthesis of some naturally occurring lactones, semiplenamides and isolation of bioactive natural products. newline6-Substituted-5,6-dihydro-2H-pyran-2-one is an important structural subunit in many biologically promising natural products. newline(6 S)-5,6-Dihydro-6-[(2 R)-2-hydroxy-6-phenylhexyl]-2H-pyran-2-one and dodoneine are amongst them that attracted our focus for newlinesynthesis due to their interesting biological activities and structural similarities. The pyranone unit of both molecules was brought newlinethrough a common intermediate with varying asymmetric centres. These lactone intermediates, ( S) - and ( R)-2-(6-oxo-3, 6-dihydro-2H-pyran-2-yl) acetaldehydes have further been accomplished from 1,3- newlinepropanediol employing Maruoka asymmetric allylation and ring closing metathesis reaction. These intermediates were converted into desired natural products (6 S)-5,6-Dihydro-6-[(2 R)-2-hydroxy-6-phenylhexyl]-2H-pyran-2-one and dodoneine through Grignard newlinereaction.
Pagination: 194 p.
URI: http://hdl.handle.net/10603/19245
Appears in Departments:Department of Chemistry

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01_title.pdfAttached File181.33 kBAdobe PDFView/Open
02_dedication.pdf152.53 kBAdobe PDFView/Open
03_declaration.pdf61.65 kBAdobe PDFView/Open
04_certificate.pdf133.88 kBAdobe PDFView/Open
05_acknowledgment.pdf133.1 kBAdobe PDFView/Open
06_remarks & abbreviations.pdf103.99 kBAdobe PDFView/Open
07_contents.pdf94.16 kBAdobe PDFView/Open
08_abstract.pdf92.38 kBAdobe PDFView/Open
09_chapter 1.pdf306.01 kBAdobe PDFView/Open
10_chapter 2.pdf4.88 MBAdobe PDFView/Open
11_chapter 3.pdf915.6 kBAdobe PDFView/Open
12_chapter 4.pdf2.99 MBAdobe PDFView/Open
13_chapter 5.pdf5.58 MBAdobe PDFView/Open
14_list of publications.pdf117.05 kBAdobe PDFView/Open


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