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Title: Isolation and Characterization of Naturally Occurring Acyltransferase or Related Class of Enzymes for Synthesis of HMG Co A Reductase Inhibitors
Researcher: Gupta, Shivani
Guide(s): Kapur, Suman
Keywords: quotBiological Science, Enzymes for Synthesis, HMG Co-A Reductase Inhibitors quot
University: Birla Institute of Technology and Science
Completed Date: 2015
Abstract: Cardiovascular diseases (one of the most common consequences of high cholesterol newlinelevels) are the most prevalent cause of death and disability in both developed as well as newlinedeveloping countries. The World Health Organization estimates that almost 20% of all newlinestrokes and over 50% of all heart attacks can be linked to high cholesterol. Most people newlinearound the globe with high cholesterol are not getting the treatment they need, claims newlinethe largest study of 147 million people, as only few people are put on cholesterol newlinelowering drugs. Statins inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) newlinereductase, which catalyzes the rate-limiting step in cholesterol biosynthesis and is most newlinepromising class of cholesterol lowering drugs. These HMGR inhibitors can reduce newlinedeath induced by coronary heart disease and heart attack rates by 20 to 50 percent. newlineNatural statins are produced as fungal secondary metabolites. Till date some terrestrial fungal strains (mainly Aspergillus terreus) is used for industrial scale production of statin molecules. Finding a novel source with a potential to synthesize HMGR inhibitor molecules will represent an important milestone in bio-catalysis of statin or their analogs and successful engineering of a biosynthetic enzyme into an industrially useful manufacturing tool would lead to substantial cost reduction and efficient synthesis of potential derivatives for therapeutic applications. This necessitates the invention of novel sources/production strategies of existing drugs to manage the increasing incidences of higher cholesterol levels. With the emerging multiple therapeutic effects (like anti inflammatory, anti cancer, bone regeneration, cognitive disorders) which are beyond just lipid lowering, these wonder drugs statins are proving to be much more powerful drugs than ever thought. The majority of fungi inhabiting the world (especially the marine resources of Indian subcontinent) and the bacterial population from unique natural sources have not yet been explored and exploited for production of
Pagination: 144p.
Appears in Departments:Biological Science

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