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Title: Optimization of Dibromoverongiaquinol and Aeroplysinin-1 as anticancer and antimicrobial drug leads
Researcher: Siddiqui, Mohammad Haris
Guide(s): Jamal, Mohammad Arif
Sayed, Khalid A El
Keywords: Biotechnology
Antimicrobial drug
Upload Date: 21-Nov-2013
University: Integral University
Completed Date: 20/04/2012
Abstract: It is well known that preclinical pipeline continues to supply several hundreds of novel marine compounds every year and those continue to feed the clinical pipeline with potentially valuable compounds. Although newlinemarine product leads have historically been confronted with many obstacles, including sustainable and extreme cytotoxicity to the newlinenormal cell types despite having advantage of being effective at many fold less concentration than the standard drugs. Traditionally, among the first options to be explored for the supply of marine derived small molecules is chemical synthesis. Unfortunately, the structural complexity of marine molecules, which suggests novel mechanisms of action and high selectivity, has also resulted in few economically newlinefeasible strategies for total chemical synthesis. Another fairly laborintensive newlinestrategy is to do studies of the biological roles of marine natural product pharmacophores with a clearly defined structural moiety, and attempt to define whether the critical pharmacophore via newlinesynthesis, chemical degradation, modification, or a combination of newlinethese, can result in more practical drugs based on a marine prototype. In the past several decades, there have been numerous drug discovery studies defining anticancer and antimicrobial molecular targets which newlinesubsequently have been validated by innumerable natural and synthetic compounds with the adaptation of the expensive and time consuming wet lab studies. Advancement in the bioinformatics tools and software enables the easy screening of multiple compounds against multiple targets, if a well validated and elucidated in-silico pathway has been newlineestablished.
Pagination: xv, 263p.
Appears in Departments:Department of Biotechnology

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01-title.pdfAttached File192.29 kBAdobe PDFView/Open
02_certificate.pdf1.06 MBAdobe PDFView/Open
03_acknowlegments.pdf76.28 kBAdobe PDFView/Open
04_abstract.pdf95.23 kBAdobe PDFView/Open
05_contents.pdf55.15 kBAdobe PDFView/Open
06_list of tables & figures.pdf241.58 kBAdobe PDFView/Open
07_reveiw of literature.pdf4.17 MBAdobe PDFView/Open
08_chapter 1.pdf681.96 kBAdobe PDFView/Open
09_chapter 2.pdf2.42 MBAdobe PDFView/Open
10_chapter 3.pdf5.05 MBAdobe PDFView/Open
11_chapter 4.pdf1.02 MBAdobe PDFView/Open
12_references & list of publications.pdf15.23 MBAdobe PDFView/Open

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