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Title: Development and evaluation of Liposomal carrier systems for hepatoprotective agents to target liver
Researcher: Nitesh Kumar
Guide(s): Rao, C Mallikarjuna
Udupa N
Kutty, N Gopalan
Keywords: Pharmaceutical Sciences
Liver cells
Upload Date: 20-Nov-2013
University: Manipal University
Completed Date: 08/08/2013
Abstract: Four widely used hepatoprotective agents namely silymarin, catechin, phyllanthin and lecithin were screened for their comparative efficacy in in vitro on Chang liver cell line and in vivo in Wistar rats against paracetamol, D-galactosamine and alcohol-induced toxicity. Silymarin was found to be most effective and formulated as diverse liposomal carrier systems namely conventional, PEGylated and charged liposomes (charged imparting agent Dicetyl phosphate and Stearyl amine). These liposomes were screened in in vitro on Chang liver cells against paracetamol, D-galactosamine and alcohol-induced toxicity. Conventional and PEGylated liposomal formulations showed better protection to Chang liver cells. Thus, these two formulations were selected for screening of in vivo hepatoprotection against the above mentioned three hepatotoxins in Wistar rats. Conventional liposomes of silymarin showed better hepatoprotection, and better anti-inflammatory effects when compared to silymarin suspension in all three hepatotoxic models. The pharmacokinetic results from the oral administration of silymarin and its conventional liposomes showed that conventional liposomes increased Cmax more than five times compared to silymarin suspension in normal rats and almost six times in alcoholic liver disease condition in rat.
Pagination: 145p.
Appears in Departments:Manipal College of Pharmaceutical Sciences

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01_title.pdfAttached File295.9 kBAdobe PDFView/Open
02_certificates.pdf937.36 kBAdobe PDFView/Open
03_abstract.pdf82.14 kBAdobe PDFView/Open
04_declaration_dedication.pdf703.64 kBAdobe PDFView/Open
05_acknowledgment.pdf235.7 kBAdobe PDFView/Open
06_content.pdf172.4 kBAdobe PDFView/Open
07_list of abbreviations.pdf275.36 kBAdobe PDFView/Open
08_list_of_tables.pdf86.88 kBAdobe PDFView/Open
09_list_of_figures.pdf275.88 kBAdobe PDFView/Open
10_chapter 1.pdf408.24 kBAdobe PDFView/Open
11_chapter 2.pdf868.25 kBAdobe PDFView/Open
12_chapter 3.pdf315.75 kBAdobe PDFView/Open
13_chapter 4.pdf532.1 kBAdobe PDFView/Open
14_chapter 5.pdf5.49 MBAdobe PDFView/Open
15_discussion_summary.pdf318.54 kBAdobe PDFView/Open
16_conclusion.pdf430.97 kBAdobe PDFView/Open
17_future direction.pdf317.46 kBAdobe PDFView/Open
18_appendix1.pdf689.49 kBAdobe PDFView/Open
19_appendix 2.pdf559.86 kBAdobe PDFView/Open
20_appendix 3.pdf494.47 kBAdobe PDFView/Open
21_appendix4.pdf1.5 MBAdobe PDFView/Open
22_references.pdf682.29 kBAdobe PDFView/Open

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