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Title: Genetic Alteration and Multidrug Resistant Gene Expression Profile of Acute Leukemia
Guide(s): Dr. Sujala Kapur
Keywords: Acute Leukemia
Genetic Alteration
University: Birla Institute of Technology and Science
Completed Date: 1/7/2012
Abstract: This dissertation aimed to find out the prevalence and significance of genetic alteration including chromosomal translocation, gene mutation, gene polymorphism and expression of genes newlineinvolved in drug resistance that may be responsible for poor outcome in patients with acute leukemia (AL). For this, patients diagnosed with acute leukemia were immunophenotyped by flow cytometry to identify and phenotypically characterize the leukemic cells. newlineImmunophenotyping is now part of the standard assessment of AL supplementing morphologic diagnosis and allowing subtyping. In the current study, most of the AL cases in children were of newlinelymphoid type (ALL) with peak incidence at 10-15 years age group whereas in adults they were typically myeloid (AML) in origin with peak incidence in the age group of 31-35 yr which was much lower than the median age of western countries (gt60 yrs). Aberrant expression of newlinelymphoid lineage associated antigen (Ly+ AML) was seen more often in cases of children than adults. CD19 was the most common aberrant lymphoid antigen expression in both adult and children followed by CD7 in AML. In B-ALL, aberrant expression of CD33 was seen more often newlinein cases of adults than children. newlineClinical and experimental data support the idea that acute leukemic blasts harbor more than one recurring mutations either chromosomal translocation or molecular mutation, suggesting a multihit model for leukemogenesis.
Pagination: 16MB
Appears in Departments:Biological Science

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