Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/12252
Title: Anti-inflammatory and anti-hyperalgesic activity of thiazolidin-4-ones and heterocyclic homoprostanoids
Researcher: Mudgal, Jayesh
Guide(s): Kutty, N Gopalan
Keywords: Pharmaceutical Sciences
Thiazolidin-4-ones
Heterocyclic homoprostanoids
Upload Date: 25-Oct-2013
University: Manipal University
Completed Date: 01/07/2013
Abstract: Inflammation is the defense mechanism by which body tries to resist the entry of invading pathogen(s) or help the body to remove the injurious stimuli and initiate the healing process. But unchecked inflammation is associated with a large number of pathological conditions like asthma, atherosclerosis, diabetes, obesity, rheumatoid arthritis, inflammatory bowel disease etc. Acute inflammation is the result of immediate response to tissue injury which results in vasodilatation, vascular leakage (edema) and leukocyte migration. Clinical signs of inflammation include heat (Calor), pain (Dolor), redness (Rubor), swelling (Tumor) and loss of function (Functio Laesa). Mucus production and smooth muscle cell constriction are also associated with acute inflammation. Pain sensation at inflamed site is modulated by the intensity and stage of inflammation. The possible outcomes of acute inflammation may be complete resolution or progression to chronic inflammation, if not resolved. For example, persistent injury or infection (ulcer, TB), prolonged toxic agent exposure (silica) and autoimmune disease states (RA, SLE). Chronic inflammation results from tissue destruction by inflammatory cells (abscess formation) and attempts taken during repair with fibrosis (excessive fibrin deposition), angiogenesis. Currently available treatments provide symptomatic relief by reducing pain. These medications do not prevent the progression of disease and are often associated with signiand#64257;cant side effects. The most widely used drugs, non-steroidal anti-inand#64258;ammatory drugs, provide incomplete and temporary pain relief . The non-pharmacological modalities such as physiotherapy, alternative, and complementary therapies are also used but have certain limitations. All this directs our attention towards the need for more effective pharmacotherapy to mitigate pain associated with arthritic conditions.
Pagination: 127p.
URI: http://hdl.handle.net/10603/12252
Appears in Departments:Manipal College of Pharmaceutical Sciences

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01_title.pdfAttached File87.5 kBAdobe PDFView/Open
02_certificates.pdf186.69 kBAdobe PDFView/Open
03_abstract.pdf105.46 kBAdobe PDFView/Open
04_declaration.pdf136.38 kBAdobe PDFView/Open
05_acknowledgement.pdf110.17 kBAdobe PDFView/Open
06_contents.pdf5.63 kBAdobe PDFView/Open
07_list of tables.pdf120.67 kBAdobe PDFView/Open
08_list of figures.pdf155.72 kBAdobe PDFView/Open
09_abbreviations.pdf155.49 kBAdobe PDFView/Open
10_chapter 1.pdf174.6 kBAdobe PDFView/Open
11_chapter 2.pdf845.98 kBAdobe PDFView/Open
12_chapter 2a.pdf112.37 kBAdobe PDFView/Open
13_chapter 3.pdf274.14 kBAdobe PDFView/Open
14_chapter 4.pdf1.88 MBAdobe PDFView/Open
15_chapter 5.pdf220.58 kBAdobe PDFView/Open
16_chapter 6.pdf167.18 kBAdobe PDFView/Open
17_summary.pdf73.89 kBAdobe PDFView/Open
18_bibliography.pdf154.77 kBAdobe PDFView/Open


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