Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/10457
Title: Chemical and biotransformation studies of some bioactive phenolics and heterocyclic compounds
Researcher: Sharma, Nandini
Guide(s): Sinha, Arun K
Keywords: Chemistry
Upload Date: 7-Aug-2013
University: Guru Nanak Dev University
Completed Date: 2011
Abstract: This thesis is divided into four chapters: Chapter 1 Biocatalytic oxidative C=C bond cleavage and C-C bond formation studies on phenolic derivatives in ionic liquid media Chapter 2 Synthesis of allylated chalcones and their derivatives with enhanced solubility for antimalarial and pesticidal activity Chapter 3 Green synthesis of some bioactive heterocyclic compounds from natural precursors Chapter 4 Isolation, chromatographic evaluation and application of phenolic rich colored compounds/fractions from plants Chapter 1: Biocatalytic oxidative C=C bond cleavage and C-C bond formation studies on phenolic derivatives in ionic liquid media The formation and cleavage of carbon-carbon bonds is of central importance in organic chemistry which provides a facile access to several commercially and biologically viable compounds. Oxidative C=C cleavage and C C coupling have been traditionally carried out with the use of metal-based catalysts. At the moment, biocatalysis has been considered to be a promising green methodology to overcome the necessity of metals in catalysis. This chapter deals with a biocatalytic approach for the metal-free direct synthesis of one or two carbon shorter aldehydes from 2o aryl alcohols through oxidative C=C bond cleavage. Furthermore, the study presents an efficient, simple and green methodology for aldol, Knoevenagel and Knoevenagel-Doebner condensations using a synergistic combination of BSA-[bmim]Br; thus highlighting the role of protein impurities in porcine pancreas lipase (rather than catalytic promiscuity) for olefinic bond formations. Chapter 2: Synthesis of allylated chalcones and their derivatives with enhanced solubility for antimalarial and pesticidal activity Chalcones and their derivatives have attracted significant attention in medicinal, synthetic and natural product chemistry due to numerous pharmacological applications among which antimalarial activity is most conspicuous.
Pagination: 224p.
URI: http://hdl.handle.net/10603/10457
Appears in Departments:Department of Chemistry

Files in This Item:
File Description SizeFormat 
01_title .pdfAttached File72.76 kBAdobe PDFView/Open
02_acknowledgement.pdf48.72 kBAdobe PDFView/Open
03_abstract.pdf103.14 kBAdobe PDFView/Open
04_content.pdf110.49 kBAdobe PDFView/Open
05_introduction.pdf582.5 kBAdobe PDFView/Open
06_chapter 1.pdf1.96 MBAdobe PDFView/Open
07_chapter 2.pdf1.94 MBAdobe PDFView/Open
08_chapter 4.pdf1.11 MBAdobe PDFView/Open
09_chapter 3.pdf1.28 MBAdobe PDFView/Open
10_list of abbreviations.pdf101.74 kBAdobe PDFView/Open
11_list_of_publications.pdf131.31 kBAdobe PDFView/Open


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